Interazioni tra farmaci
Deflazacort + Somapacitan
Gravità: Moderata
Deflazacort and Somapacitan: moderate interaction.
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Sintesi
Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
Cosa significa questa interazione in parole semplici
Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somapacitan belongs to Endocrine.
Perché avviene
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 reducing cortisol activation.
Cosa fare
Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Controindicata
- Bcg vaccine live + Deflazacort Controindicata
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Controindicata
- Deflazacort + Measles mumps and rubella vaccine Controindicata
- Deflazacort + Measles mumps and rubella vaccine live Controindicata
- Deflazacort + Measles mumps rubella and varicella vaccine live Controindicata
Altre interazioni di Somapacitan
- Alogliptin-metformin + Somapacitan Moderata
- Alogliptin-pioglitazone + Somapacitan Moderata
- Alogliptin + Somapacitan Moderata
- Bazedoxifene-conjugated estrogens + Somapacitan Moderata
- Canagliflozin-metformin + Somapacitan Moderata
- Chlorpropamide + Somapacitan Moderata
Domande frequenti
Can I take Deflazacort with Somapacitan?
MediHelp rates the interaction as moderate. Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
How serious is the interaction between Deflazacort and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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