Interazioni tra farmaci
Deflazacort + Somatrogon
Gravità: Moderata
Deflazacort and Somatrogon: moderate interaction.
Ultimo aggiornamento
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Sintesi
High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.
Cosa significa questa interazione in parole semplici
Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somatrogon belongs to Endocrine.
Perché avviene
Pharmacodynamic antagonism of growth hormone by glucocorticoids and growth hormone inhibition of 11-beta-HSD1.
Cosa fare
Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Controindicata
- Bcg vaccine live + Deflazacort Controindicata
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Controindicata
- Deflazacort + Measles mumps and rubella vaccine Controindicata
- Deflazacort + Measles mumps and rubella vaccine live Controindicata
- Deflazacort + Measles mumps rubella and varicella vaccine live Controindicata
Altre interazioni di Somatrogon
- Alogliptin-metformin + Somatrogon Moderata
- Alogliptin-pioglitazone + Somatrogon Moderata
- Alogliptin + Somatrogon Moderata
- Canagliflozin-metformin + Somatrogon Moderata
- Chlorpropamide + Somatrogon Moderata
- Cyclosporin + Somatrogon Moderata
Domande frequenti
Can I take Deflazacort with Somatrogon?
MediHelp rates the interaction as moderate. Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.
How serious is the interaction between Deflazacort and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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