Interazioni tra farmaci
Deutetrabenazine + Rasagiline
Gravità: Controindicata
Deutetrabenazine and Rasagiline: contraindicated interaction.
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Sintesi
Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping one. The combination may cause hypertension and excess monoaminergic effects.
Cosa significa questa interazione in parole semplici
Deutetrabenazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Perché avviene
Deutetrabenazine depletes vesicular monoamines, and with MAO inhibition the released monoamines are not degraded, leading to unstable sympathetic effects.
Cosa fare
Do not co-administer and keep a 14-day gap after stopping the MAO inhibitor. Consider another treatment for chorea or tardive dyskinesia.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Rasagiline
- Atomoxetine + Rasagiline Controindicata
- Brimonidine + Rasagiline Controindicata
- Bupropion-naltrexone + Rasagiline Controindicata
- Bupropion + Rasagiline Controindicata
- Clomipramine + Rasagiline Controindicata
- Desvenlafaxine + Rasagiline Controindicata
Altre interazioni di Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Controindicata
- Deutetrabenazine + Linezolid Controindicata
- Deutetrabenazine + Phenelzine Controindicata
- Deutetrabenazine + Safinamide Controindicata
- Deutetrabenazine + Selegiline Controindicata
- Deutetrabenazine + Tranylcypromine Controindicata
Domande frequenti
Can I take Deutetrabenazine with Rasagiline?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping one. The combination may cause hypertension and excess monoaminergic effects.
How serious is the interaction between Deutetrabenazine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and keep a 14-day gap after stopping the MAO inhibitor. Consider another treatment for chorea or tardive dyskinesia.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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