Interazioni tra farmaci
Deutetrabenazine + Selegiline
Gravità: Controindicata
Deutetrabenazine and Selegiline: contraindicated interaction.
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Sintesi
Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
Cosa significa questa interazione in parole semplici
Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Perché avviene
Deutetrabenazine depletes and releases monoamines while MAO inhibition blocks their breakdown, so catecholamines can accumulate and cause a pressor response.
Cosa fare
Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Altre interazioni di Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Controindicata
- Deutetrabenazine + Linezolid Controindicata
- Deutetrabenazine + Phenelzine Controindicata
- Deutetrabenazine + Rasagiline Controindicata
- Deutetrabenazine + Safinamide Controindicata
- Deutetrabenazine + Tranylcypromine Controindicata
Domande frequenti
Can I take Deutetrabenazine with Selegiline?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
How serious is the interaction between Deutetrabenazine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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