Interazioni tra farmaci
Deutetrabenazine + Isocarboxazid
Gravità: Controindicata
Deutetrabenazine and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Deutetrabenazine must not be used with MAOIs. Combination may cause marked blood pressure and heart rate changes, and monoamine depletion with MAO inhibition is unpredictable.
Cosa significa questa interazione in parole semplici
Deutetrabenazine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Perché avviene
VMAT2 inhibition alters monoamine storage while MAO inhibition blocks their breakdown, causing unpredictable adrenergic effects.
Cosa fare
Avoid concurrent use and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Consider other management of chorea or tardive dyskinesia.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Altre interazioni di Deutetrabenazine
- Deutetrabenazine + Linezolid Controindicata
- Deutetrabenazine + Phenelzine Controindicata
- Deutetrabenazine + Rasagiline Controindicata
- Deutetrabenazine + Safinamide Controindicata
- Deutetrabenazine + Selegiline Controindicata
- Deutetrabenazine + Tranylcypromine Controindicata
Domande frequenti
Can I take Deutetrabenazine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine must not be used with MAOIs. Combination may cause marked blood pressure and heart rate changes, and monoamine depletion with MAO inhibition is unpredictable.
How serious is the interaction between Deutetrabenazine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Consider other management of chorea or tardive dyskinesia.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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