Interazioni tra farmaci
Dextroamphetamine + Methylene blue
Gravità: Controindicata
Dextroamphetamine and Methylene blue: contraindicated interaction.
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Sintesi
Methylene blue inhibits monoamine oxidase A and, with serotonergic or sympathomimetic drugs, can cause serotonin syndrome. Amphetamine adds serotonin and norepinephrine release, and hypertensive reactions are also possible.
Cosa significa questa interazione in parole semplici
Dextroamphetamine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO-A inhibition by methylene blue combined with amphetamine-induced monoamine release.
Cosa fare
Avoid the combination. If urgent methylene blue treatment is needed, stop the amphetamine and monitor for serotonin toxicity for at least 24 hours after the last methylene blue dose, or until two weeks have passed if the methylene blue is not given.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Controindicata
- Dextroamphetamine + Linezolid Controindicata
- Dextroamphetamine + Phenelzine Controindicata
- Dextroamphetamine + Rasagiline Controindicata
- Dextroamphetamine + Safinamide Controindicata
- Dextroamphetamine + Selegiline Controindicata
Domande frequenti
Can I take Dextroamphetamine with Methylene blue?
MediHelp rates the interaction as contraindicated. Dextroamphetamine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A and, with serotonergic or sympathomimetic drugs, can cause serotonin syndrome. Amphetamine adds serotonin and norepinephrine release, and hypertensive reactions are also possible.
How serious is the interaction between Dextroamphetamine and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If urgent methylene blue treatment is needed, stop the amphetamine and monitor for serotonin toxicity for at least 24 hours after the last methylene blue dose, or until two weeks have passed if the methylene blue is not given.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextroamphetamine page.
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