Interazioni tra farmaci
Dextroamphetamine + Safinamide
Gravità: Controindicata
Dextroamphetamine and Safinamide: contraindicated interaction.
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Sintesi
Safinamide inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
Cosa significa questa interazione in parole semplici
Dextroamphetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dextroamphetamine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Perché avviene
MAO inhibition plus indirect sympathomimetic norepinephrine release -> exaggerated pressor response
Cosa fare
Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Controindicata
- Dextroamphetamine + Linezolid Controindicata
- Dextroamphetamine + Methylene blue Controindicata
- Dextroamphetamine + Phenelzine Controindicata
- Dextroamphetamine + Rasagiline Controindicata
- Dextroamphetamine + Selegiline Controindicata
Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Clomipramine + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
Domande frequenti
Can I take Dextroamphetamine with Safinamide?
MediHelp rates the interaction as contraindicated. Dextroamphetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
How serious is the interaction between Dextroamphetamine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give dextroamphetamine during or within 14 days of an MAO inhibitor, and leave at least 14 days after stopping the stimulant before starting the MAO inhibitor.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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