Interazioni tra farmaci
Dextroamphetamine + Linezolid
Gravità: Controindicata
Dextroamphetamine and Linezolid: contraindicated interaction.
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Sintesi
Linezolid inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
Cosa significa questa interazione in parole semplici
Dextroamphetamine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dextroamphetamine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Perché avviene
MAO inhibition plus indirect sympathomimetic norepinephrine release -> exaggerated pressor response
Cosa fare
Do not give dextroamphetamine during or within 14 days of an MAO inhibitor; if the oxazolidinone is unavoidable, use only with intensive blood-pressure monitoring and avoid the stimulant.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Linezolid
- Amoxapine + Linezolid Controindicata
- Atomoxetine + Linezolid Controindicata
- Benzphetamine + Linezolid Controindicata
- Brimonidine + Linezolid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion + Linezolid Controindicata
Altre interazioni di Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Controindicata
- Dextroamphetamine + Methylene blue Controindicata
- Dextroamphetamine + Phenelzine Controindicata
- Dextroamphetamine + Rasagiline Controindicata
- Dextroamphetamine + Safinamide Controindicata
- Dextroamphetamine + Selegiline Controindicata
Domande frequenti
Can I take Dextroamphetamine with Linezolid?
MediHelp rates the interaction as contraindicated. Dextroamphetamine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid inhibits catecholamine breakdown and enlarges neuronal norepinephrine stores, and dextroamphetamine releases norepinephrine and dopamine from nerve terminals. The result can be a hypertensive crisis with severe headache, arrhythmia, hyperpyrexia and intracranial haemorrhage.
How serious is the interaction between Dextroamphetamine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give dextroamphetamine during or within 14 days of an MAO inhibitor; if the oxazolidinone is unavoidable, use only with intensive blood-pressure monitoring and avoid the stimulant.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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