Interazioni tra farmaci
Digoxin + Penicillamine
Gravità: Moderata
Digoxin and Penicillamine: moderate interaction.
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Sintesi
Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
Cosa significa questa interazione in parole semplici
Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.
Perché avviene
Mechanism not established; reduced digoxin absorption has been suggested.
Cosa fare
Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Penicillamine
- Gold sodium thiomalate + Penicillamine Maggiore
- Aluminum hydroxide + Penicillamine Moderata
- Calcium carbonate + Penicillamine Moderata
- Calcium + Penicillamine Moderata
- Carbonyl iron + Penicillamine Moderata
- Copper + Penicillamine Moderata
Altre interazioni di Digoxin
- Digoxin + Lily of the valley Controindicata
- Digoxin + Squill Controindicata
- Adagrasib + Digoxin Maggiore
- Amiodarone + Digoxin Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Maggiore
- Amphotericin b deoxycholate + Digoxin Maggiore
Domande frequenti
Can I take Digoxin with Penicillamine?
MediHelp rates the interaction as moderate. Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
How serious is the interaction between Digoxin and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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