Interazioni tra farmaci
Digoxin + Remibrutinib
Gravità: Moderata
Digoxin and Remibrutinib: moderate interaction.
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Sintesi
Remibrutinib inhibits P-glycoprotein and may increase digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels may cause toxicity such as arrhythmias, nausea and visual disturbances.
Cosa significa questa interazione in parole semplici
Digoxin and Remibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Remibrutinib belongs to Oncology.
Perché avviene
P-glycoprotein inhibition reduces digoxin efflux and renal clearance, increasing exposure.
Cosa fare
Monitor serum digoxin concentrations and signs of toxicity when starting or stopping remibrutinib. Reduce the digoxin dose if concentrations rise.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Digoxin
- Digoxin + Lily of the valley Controindicata
- Digoxin + Squill Controindicata
- Adagrasib + Digoxin Maggiore
- Amiodarone + Digoxin Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Maggiore
- Amphotericin b deoxycholate + Digoxin Maggiore
Domande frequenti
Can I take Digoxin with Remibrutinib?
MediHelp rates the interaction as moderate. Digoxin and Remibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remibrutinib inhibits P-glycoprotein and may increase digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels may cause toxicity such as arrhythmias, nausea and visual disturbances.
How serious is the interaction between Digoxin and Remibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and signs of toxicity when starting or stopping remibrutinib. Reduce the digoxin dose if concentrations rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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