Drug interactions
Digoxin + Remibrutinib
Severity: Moderate
Digoxin and Remibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remibrutinib inhibits P-glycoprotein and may increase digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels may cause toxicity such as arrhythmias, nausea and visual disturbances.
What this interaction means in plain words
Digoxin and Remibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Remibrutinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition reduces digoxin efflux and renal clearance, increasing exposure.
What to do
Monitor serum digoxin concentrations and signs of toxicity when starting or stopping remibrutinib. Reduce the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Remibrutinib?
MediHelp rates the interaction as moderate. Digoxin and Remibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remibrutinib inhibits P-glycoprotein and may increase digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels may cause toxicity such as arrhythmias, nausea and visual disturbances.
How serious is the interaction between Digoxin and Remibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and signs of toxicity when starting or stopping remibrutinib. Reduce the digoxin dose if concentrations rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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