Drug interactions
Dihydroergotamine + Idelalisib
Severity: Contraindicated
Dihydroergotamine and Idelalisib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib may greatly increase dihydroergotamine levels, raising the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
What this interaction means in plain words
Dihydroergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib's metabolite reduces dihydroergotamine clearance.
What to do
Avoid the combination and use another migraine therapy during idelalisib treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
- Ergotamine + Idelalisib Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Idelalisib?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib may greatly increase dihydroergotamine levels, raising the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use another migraine therapy during idelalisib treatment.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Cisapride, Dronedarone. The full list is on the Idelalisib page.
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