Interazioni tra farmaci
Dihydroergotamine intranasal + Fluconazole
Gravità: Controindicata
Dihydroergotamine intranasal and Fluconazole: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Fluconazole can raise dihydroergotamine exposure through CYP3A4 inhibition, even with intranasal use. This raises the risk of ergotism with vasospasm and limb or cerebral ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine intranasal and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Inhibition of CYP3A4-mediated dihydroergotamine metabolism by fluconazole.
Cosa fare
Avoid the combination and use an alternative acute migraine treatment during fluconazole therapy. Stop dihydroergotamine and seek urgent care if numbness, coldness or pain in the extremities develops.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
- Fluconazole + Levoketoconazole Controindicata
Domande frequenti
Can I take Dihydroergotamine intranasal with Fluconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole can raise dihydroergotamine exposure through CYP3A4 inhibition, even with intranasal use. This raises the risk of ergotism with vasospasm and limb or cerebral ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative acute migraine treatment during fluconazole therapy. Stop dihydroergotamine and seek urgent care if numbness, coldness or pain in the extremities develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine, Dofetilide, Dronedarone. The full list is on the Fluconazole page.
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