Interazioni tra farmaci
Fluconazole + Levoketoconazole
Gravità: Controindicata
Fluconazole and Levoketoconazole: contraindicated interaction.
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Sintesi
Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
Cosa significa questa interazione in parole semplici
Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Levoketoconazole belongs to Endocrine.
Perché avviene
Additive QT prolongation, with possible metabolic inhibition raising levoketoconazole levels.
Cosa fare
Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Clarithromycin + Levoketoconazole Controindicata
Domande frequenti
Can I take Fluconazole with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
How serious is the interaction between Fluconazole and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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