Interazioni tra farmaci
Dofetilide + Fluconazole
Gravità: Controindicata
Dofetilide and Fluconazole: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, and fluconazole may also reduce dofetilide elimination, raising its levels. This markedly increases the risk of torsades de pointes and fatal ventricular arrhythmia.
Cosa significa questa interazione in parole semplici
Dofetilide and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Perché avviene
Additive QT prolongation, with possible fluconazole-related increase in dofetilide exposure via CYP3A4 and renal transport inhibition.
Cosa fare
Avoid the combination; use a non-QT-prolonging antifungal. If systemic azole therapy is essential, consider an alternative antiarrhythmic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
- Fluconazole + Levoketoconazole Controindicata
Altre interazioni di Dofetilide
- Amiodarone + Dofetilide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Captopril-hydrochlorothiazide + Dofetilide Controindicata
Domande frequenti
Can I take Dofetilide with Fluconazole?
MediHelp rates the interaction as contraindicated. Dofetilide and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and fluconazole may also reduce dofetilide elimination, raising its levels. This markedly increases the risk of torsades de pointes and fatal ventricular arrhythmia.
How serious is the interaction between Dofetilide and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging antifungal. If systemic azole therapy is essential, consider an alternative antiarrhythmic.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dronedarone. The full list is on the Fluconazole page.
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