Interazioni tra farmaci
Dihydroergotamine + Fluconazole
Gravità: Controindicata
Dihydroergotamine and Fluconazole: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Perché avviene
Inhibition of CYP3A4-mediated dihydroergotamine metabolism by fluconazole.
Cosa fare
Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Dihydroergotamine e Fluconazole, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
- Fluconazole + Levoketoconazole Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Fluconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dofetilide, Dronedarone. The full list is on the Fluconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
