Interazioni tra farmaci
Dofetilide + Nortriptyline
Gravità: Controindicata
Dofetilide and Nortriptyline: contraindicated interaction.
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Sintesi
Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.
Cosa significa questa interazione in parole semplici
Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Nortriptyline belongs to Central Nervous System.
Perché avviene
Additive prolongation of cardiac repolarization via potassium channel effects.
Cosa fare
Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Nortriptyline
- Disopyramide + Nortriptyline Controindicata
- Dronedarone + Nortriptyline Controindicata
- Ibutilide + Nortriptyline Controindicata
- Isocarboxazid + Nortriptyline Controindicata
- Methylene blue + Nortriptyline Controindicata
- Nortriptyline + Pentamidine Controindicata
Altre interazioni di Dofetilide
- Amiodarone + Dofetilide Controindicata
- Amisulpride + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Captopril-hydrochlorothiazide + Dofetilide Controindicata
Domande frequenti
Can I take Dofetilide with Nortriptyline?
MediHelp rates the interaction as contraindicated. Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Dofetilide and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dronedarone, Ibutilide. The full list is on the Nortriptyline page.
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