Drug interactions
Elagolix + Ethinyl estradiol-drospirenone
Severity: Major
Elagolix and Ethinyl estradiol-drospirenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.
What this interaction means in plain words
Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: exogenous estrogen opposes elagolix's suppression of estrogen.
What to do
Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
- Elagolix + Ketoconazole Major
Frequently asked questions
Can I take Elagolix with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as major. Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.
How serious is the interaction between Elagolix and Ethinyl estradiol-drospirenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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