Drug interactions
Eletriptan + Lopinavir
Severity: Contraindicated
Eletriptan and Lopinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
What this interaction means in plain words
Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition (mainly by the ritonavir component) reducing eletriptan clearance.
What to do
Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
Frequently asked questions
Can I take Eletriptan with Lopinavir?
MediHelp rates the interaction as contraindicated. Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
How serious is the interaction between Eletriptan and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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