Interazioni tra farmaci
Fingolimod + Siponimod
Gravità: Controindicata
Fingolimod and Siponimod: contraindicated interaction.
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Sintesi
Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
Cosa significa questa interazione in parole semplici
Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Perché avviene
Duplicate S1P receptor modulation with additive negative chronotropic and immunosuppressive effects.
Cosa fare
Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Controindicata
- Bcg vaccine live + Fingolimod Controindicata
- Fingolimod + Pimozide Controindicata
- Fingolimod + Ponesimod Controindicata
- Fingolimod + Quinidine Controindicata
- Fingolimod + Sotalol Controindicata
Altre interazioni di Siponimod
- Cladribine + Siponimod Controindicata
- Fluconazole + Siponimod Controindicata
- Influenza virus vaccine quadrivalent intranasal + Siponimod Controindicata
- Ponesimod + Siponimod Controindicata
- Siponimod + Thioridazine Controindicata
- Adenovirus types 4 and 7 live + Siponimod Maggiore
Domande frequenti
Can I take Fingolimod with Siponimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
How serious is the interaction between Fingolimod and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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