Interazioni tra farmaci
Ponesimod + Siponimod
Gravità: Controindicata
Ponesimod and Siponimod: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Both are sphingosine-1-phosphate receptor modulators with the same class effects, including heart rate reduction and immunosuppression. Using them together adds no established benefit and increases the risk of bradyarrhythmia and infection.
Cosa significa questa interazione in parole semplici
Ponesimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ponesimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Perché avviene
Duplicate S1P receptor modulation produces additive effects on heart rate, AV conduction and lymphocyte reduction.
Cosa fare
Do not combine these drugs. When switching between them, stop one and allow for its washout and lymphocyte recovery before starting the other, as advised in labeling.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Siponimod
- Cladribine + Siponimod Controindicata
- Fingolimod + Siponimod Controindicata
- Fluconazole + Siponimod Controindicata
- Influenza virus vaccine quadrivalent intranasal + Siponimod Controindicata
- Siponimod + Thioridazine Controindicata
- Adenovirus types 4 and 7 live + Siponimod Maggiore
Altre interazioni di Ponesimod
- Fingolimod + Ponesimod Controindicata
- Amiodarone + Ponesimod Maggiore
- Amisulpride + Ponesimod Maggiore
- Anagrelide + Ponesimod Maggiore
- Anti-thymocyte + Ponesimod Maggiore
- Asenapine + Ponesimod Maggiore
Domande frequenti
Can I take Ponesimod with Siponimod?
MediHelp rates the interaction as contraindicated. Ponesimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators with the same class effects, including heart rate reduction and immunosuppression. Using them together adds no established benefit and increases the risk of bradyarrhythmia and infection.
How serious is the interaction between Ponesimod and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine these drugs. When switching between them, stop one and allow for its washout and lymphocyte recovery before starting the other, as advised in labeling.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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