Interazioni tra farmaci
Fluconazole + Siponimod
Gravità: Controindicata
Fluconazole and Siponimod: contraindicated interaction.
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Sintesi
Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.
Cosa significa questa interazione in parole semplici
Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Siponimod belongs to Central Nervous System.
Perché avviene
Combined moderate inhibition of CYP2C9 and CYP3A4 by fluconazole reduces siponimod clearance.
Cosa fare
Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Siponimod
- Cladribine + Siponimod Controindicata
- Fingolimod + Siponimod Controindicata
- Influenza virus vaccine quadrivalent intranasal + Siponimod Controindicata
- Ponesimod + Siponimod Controindicata
- Siponimod + Thioridazine Controindicata
- Adenovirus types 4 and 7 live + Siponimod Maggiore
Domande frequenti
Can I take Fluconazole with Siponimod?
MediHelp rates the interaction as contraindicated. Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.
How serious is the interaction between Fluconazole and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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