Interazioni tra farmaci
Fluconazole + Glimepiride
Gravità: Maggiore
Fluconazole and Glimepiride: major interaction.
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Sintesi
Fluconazole raises glimepiride concentrations, increasing the risk of prolonged and severe hypoglycemia. The effect is clinically important, particularly in older patients and those with renal impairment.
Cosa significa questa interazione in parole semplici
Fluconazole and Glimepiride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glimepiride belongs to Endocrine.
Perché avviene
Fluconazole inhibits CYP2C9, the main enzyme metabolizing glimepiride.
Cosa fare
Monitor blood glucose closely and reduce the glimepiride dose when fluconazole is started. Counsel the patient on hypoglycemia symptoms.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Glimepiride
- Glimepiride + Insulin degludec-liraglutide Maggiore
- Glimepiride + Insulin glargine-lixisenatide Maggiore
- Glimepiride + Sulfamethoxazole Maggiore
- Aceclofenac + Glimepiride Moderata
- Acemetacin + Glimepiride Moderata
- Acetylsalicylic acid + Glimepiride Moderata
Domande frequenti
Can I take Fluconazole with Glimepiride?
MediHelp rates the interaction as major. Fluconazole and Glimepiride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glimepiride concentrations, increasing the risk of prolonged and severe hypoglycemia. The effect is clinically important, particularly in older patients and those with renal impairment.
How serious is the interaction between Fluconazole and Glimepiride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glimepiride dose when fluconazole is started. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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