Interazioni tra farmaci
Fluconazole + Selumetinib
Gravità: Maggiore
Fluconazole and Selumetinib: major interaction.
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Sintesi
Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.
Cosa significa questa interazione in parole semplici
Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Selumetinib belongs to Oncology.
Perché avviene
Fluconazole inhibits CYP3A4 metabolism of selumetinib.
Cosa fare
Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Fluconazole
- Dihydroergotamine intranasal + Fluconazole Controindicata
- Dihydroergotamine + Fluconazole Controindicata
- Dofetilide + Fluconazole Controindicata
- Dronedarone + Fluconazole Controindicata
- Erythromycin + Fluconazole Controindicata
- Flibanserin + Fluconazole Controindicata
Altre interazioni di Selumetinib
- Amobarbital + Selumetinib Maggiore
- Apalutamide + Selumetinib Maggiore
- Aprepitant + Selumetinib Maggiore
- Carbamazepine + Selumetinib Maggiore
- Chloramphenicol + Selumetinib Maggiore
- Clarithromycin + Selumetinib Maggiore
Domande frequenti
Can I take Fluconazole with Selumetinib?
MediHelp rates the interaction as major. Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.
How serious is the interaction between Fluconazole and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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