Interazioni tra farmaci
Folic acid + Fosphenytoin
Gravità: Moderata
Folic acid and Fosphenytoin: moderate interaction.
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Sintesi
Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
Cosa significa questa interazione in parole semplici
Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Fosphenytoin belongs to Central Nervous System.
Perché avviene
Folate may increase phenytoin metabolism; the exact mechanism is not firmly established.
Cosa fare
Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Folic acid
- Ethotoin + Folic acid Moderata
- Folic acid + Glucarpidase Moderata
- Folic acid + Methotrexate Moderata
- Folic acid + Pafolacianine Moderata
- Folic acid + Phenobarbital Moderata
- Folic acid + Phenytoin Moderata
Altre interazioni di Fosphenytoin
- Dronedarone + Fosphenytoin Controindicata
- Fosphenytoin + Ledipasvir-sofosbuvir Controindicata
- Fosphenytoin + Lorlatinib Controindicata
- Fosphenytoin + Lurasidone Controindicata
- Fosphenytoin + Ranolazine Controindicata
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
Domande frequenti
Can I take Folic acid with Fosphenytoin?
MediHelp rates the interaction as moderate. Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
How serious is the interaction between Folic acid and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Glucarpidase, Methotrexate. The full list is on the Folic acid page.
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