Interazioni tra farmaci
Folic acid + Phenytoin
Gravità: Moderata
Folic acid and Phenytoin: moderate interaction.
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Sintesi
Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
Cosa significa questa interazione in parole semplici
Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Perché avviene
Folate may increase the hepatic metabolism of phenytoin, while phenytoin impairs folate absorption and status.
Cosa fare
Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Doravirine + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
Altre interazioni di Folic acid
- Ethotoin + Folic acid Moderata
- Folic acid + Fosphenytoin Moderata
- Folic acid + Glucarpidase Moderata
- Folic acid + Methotrexate Moderata
- Folic acid + Pafolacianine Moderata
- Folic acid + Phenobarbital Moderata
Domande frequenti
Can I take Folic acid with Phenytoin?
MediHelp rates the interaction as moderate. Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
How serious is the interaction between Folic acid and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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