Interazioni tra farmaci
Folic acid + Glucarpidase
Gravità: Moderata
Folic acid and Glucarpidase: moderate interaction.
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Sintesi
Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
Cosa significa questa interazione in parole semplici
Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Glucarpidase belongs to Miscellaneous.
Perché avviene
Glucarpidase is a carboxypeptidase that cleaves the terminal glutamate residue from folates, inactivating them.
Cosa fare
Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Folic acid
- Ethotoin + Folic acid Moderata
- Folic acid + Fosphenytoin Moderata
- Folic acid + Methotrexate Moderata
- Folic acid + Pafolacianine Moderata
- Folic acid + Phenobarbital Moderata
- Folic acid + Phenytoin Moderata
Altre interazioni di Glucarpidase
- Glucarpidase + Leucovorin Maggiore
- Glucarpidase + Methotrexate Moderata
- Glucarpidase + Pemetrexed Minore
- Glucarpidase + Pralatrexate Minore
Domande frequenti
Can I take Folic acid with Glucarpidase?
MediHelp rates the interaction as moderate. Folic acid and Glucarpidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucarpidase hydrolyzes folates and antifolates such as methotrexate, and can degrade folic acid and related folate compounds like leucovorin. Folate rescue given around glucarpidase may therefore be less effective.
How serious is the interaction between Folic acid and Glucarpidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give leucovorin within 2 hours before or after glucarpidase, since it is a substrate, and continue folate rescue as directed by the protocol afterward.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Methotrexate. The full list is on the Folic acid page.
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