Interazioni tra farmaci
Glucarpidase + Pemetrexed
Gravità: Minore
Glucarpidase and Pemetrexed: minor interaction.
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Sintesi
Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
Cosa significa questa interazione in parole semplici
Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucarpidase belongs to Miscellaneous; Pemetrexed belongs to Oncology.
Perché avviene
Glucarpidase hydrolyzes the terminal glutamate of antifolates, potentially inactivating pemetrexed.
Cosa fare
Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
Cosa chiedere al farmacista
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Altre interazioni di Pemetrexed
- Bacitracin + Pemetrexed Maggiore
- Brexucabtagene autoleucel + Pemetrexed Maggiore
- Celecoxib + Pemetrexed Maggiore
- Ciltacabtagene autoleucel + Pemetrexed Maggiore
- Deferiprone + Pemetrexed Maggiore
- Dengue vaccine + Pemetrexed Maggiore
Altre interazioni di Glucarpidase
- Glucarpidase + Leucovorin Maggiore
- Folic acid + Glucarpidase Moderata
- Glucarpidase + Methotrexate Moderata
- Glucarpidase + Pralatrexate Minore
Domande frequenti
Can I take Glucarpidase with Pemetrexed?
MediHelp rates the interaction as minor. Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
How serious is the interaction between Glucarpidase and Pemetrexed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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