Interazioni tra farmaci
Glycerol phenylbutyrate + Haloperidol
Gravità: Moderata
Glycerol phenylbutyrate and Haloperidol: moderate interaction.
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Sintesi
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
Cosa significa questa interazione in parole semplici
Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Perché avviene
Haloperidol may increase blood ammonia, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate; the mechanism is not fully established.
Cosa fare
Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Haloperidol
- Dofetilide + Haloperidol Controindicata
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- Haloperidol + Ibutilide Controindicata
- Haloperidol + Levoketoconazole Controindicata
- Haloperidol + Panobinostat Controindicata
- Haloperidol + Pimozide Controindicata
Altre interazioni di Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Maggiore
- Glycerol phenylbutyrate + Sodium valproate Maggiore
- Glycerol phenylbutyrate + Valproic acid Maggiore
- Cyclosporin + Glycerol phenylbutyrate Moderata
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderata
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderata
Domande frequenti
Can I take Glycerol phenylbutyrate with Haloperidol?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
How serious is the interaction between Glycerol phenylbutyrate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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