Interazioni tra farmaci
Heparin + Ketorolac
Gravità: Controindicata
Heparin and Ketorolac: contraindicated interaction.
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Sintesi
Ketorolac inhibits platelet function and can cause GI bleeding, and heparin is an anticoagulant, so serious bleeding risk is markedly higher. Ketorolac labeling contraindicates its use in patients at risk of bleeding, including those receiving anticoagulants.
Cosa significa questa interazione in parole semplici
Heparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Heparin belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Perché avviene
Additive hemostatic impairment from NSAID platelet inhibition and heparin-mediated antithrombin potentiation.
Cosa fare
Avoid ketorolac in patients on therapeutic heparin and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin and aPTT.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ketorolac
- Aceclofenac + Ketorolac Controindicata
- Acemetacin + Ketorolac Controindicata
- Acetylsalicylic acid + Ketorolac Controindicata
- Apixaban + Ketorolac Controindicata
- Argatroban + Ketorolac Controindicata
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Controindicata
Altre interazioni di Heparin
- Defibrotide + Heparin Controindicata
- Heparin + Oritavancin Controindicata
- Acemetacin + Heparin Maggiore
- Acetylsalicylic acid + Heparin Maggiore
- Alteplase + Heparin Maggiore
- Andexanet alfa + Heparin Maggiore
Domande frequenti
Can I take Heparin with Ketorolac?
MediHelp rates the interaction as contraindicated. Heparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause GI bleeding, and heparin is an anticoagulant, so serious bleeding risk is markedly higher. Ketorolac labeling contraindicates its use in patients at risk of bleeding, including those receiving anticoagulants.
How serious is the interaction between Heparin and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on therapeutic heparin and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin and aPTT.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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