Interazioni tra farmaci
Hydrocodone + Olanzapine / samidorphan
Gravità: Controindicata
Hydrocodone and Olanzapine / samidorphan: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Samidorphan blocks opioid receptors, reducing hydrocodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Escalating opioid doses to overcome the blockade is dangerous.
Cosa significa questa interazione in parole semplici
Hydrocodone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Samidorphan is a mu-opioid receptor antagonist that opposes hydrocodone's agonist effects.
Cosa fare
Ensure at least 7 days opioid-free for short-acting opioids before starting. Use an alternative antipsychotic in patients requiring opioids.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Hydrocodone
- Alvimopan + Hydrocodone Controindicata
- Bupropion-naltrexone + Hydrocodone Controindicata
- Hydrocodone + Isocarboxazid Controindicata
- Hydrocodone + Phenelzine Controindicata
- Alfentanil + Hydrocodone Maggiore
- Alprazolam + Hydrocodone Maggiore
Domande frequenti
Can I take Hydrocodone with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Hydrocodone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing hydrocodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Escalating opioid doses to overcome the blockade is dangerous.
How serious is the interaction between Hydrocodone and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure at least 7 days opioid-free for short-acting opioids before starting. Use an alternative antipsychotic in patients requiring opioids.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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