Interazioni tra farmaci
Hydrocodone + Isocarboxazid
Gravità: Controindicata
Hydrocodone and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.
Cosa significa questa interazione in parole semplici
Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocodone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Nonselective MAO inhibition raises serotonergic and noradrenergic activity and may alter opioid effects, causing serotonin toxicity or CNS depression.
Cosa fare
Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Hydrocodone e Isocarboxazid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Hydrocodone
- Alvimopan + Hydrocodone Controindicata
- Bupropion-naltrexone + Hydrocodone Controindicata
- Hydrocodone + Olanzapine / samidorphan Controindicata
- Hydrocodone + Phenelzine Controindicata
- Alfentanil + Hydrocodone Maggiore
- Alprazolam + Hydrocodone Maggiore
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Hydrocodone with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Hydrocodone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids can cause serotonin syndrome or unpredictable opioid toxicity, including respiratory depression and coma. The risk persists for about two weeks after the MAOI is stopped.
How serious is the interaction between Hydrocodone and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use hydrocodone during or within 14 days of an MAOI; choose a non-opioid or non-interacting analgesic. If an opioid is unavoidable, use closely monitored small test doses.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydrocodone page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
