Interazioni tra farmaci
Hydrocodone + Phenelzine
Gravità: Controindicata
Hydrocodone and Phenelzine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
Cosa significa questa interazione in parole semplici
Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocodone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Perché avviene
Inhibition of monoamine oxidase raises serotonergic and noradrenergic activity, with possible potentiation of opioid CNS effects.
Cosa fare
Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Additional notes
- Evidence detail
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Altre interazioni di Hydrocodone
- Alvimopan + Hydrocodone Controindicata
- Bupropion-naltrexone + Hydrocodone Controindicata
- Hydrocodone + Isocarboxazid Controindicata
- Hydrocodone + Olanzapine / samidorphan Controindicata
- Alfentanil + Hydrocodone Maggiore
- Alprazolam + Hydrocodone Maggiore
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Hydrocodone with Phenelzine?
MediHelp rates the interaction as contraindicated. Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
How serious is the interaction between Hydrocodone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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