Interazioni tra farmaci
Hydroxychloroquine + Pimozide
Gravità: Controindicata
Hydroxychloroquine and Pimozide: contraindicated interaction.
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Sintesi
Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
Cosa significa questa interazione in parole semplici
Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Perché avviene
Additive QT prolongation via hERG potassium channel blockade.
Cosa fare
Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Controindicata
- Cisapride + Hydroxychloroquine Controindicata
- Dronedarone + Hydroxychloroquine Controindicata
- Hydroxychloroquine + Thioridazine Controindicata
- Hydroxychloroquine + Vandetanib Controindicata
- Adagrasib + Hydroxychloroquine Maggiore
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Hydroxychloroquine with Pimozide?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide has a marked QT-prolonging effect and hydroxychloroquine adds to this, increasing the chance of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against combination with other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative antimalarial or antirheumatic agent, or a different antipsychotic, in place of one of the two.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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