Interazioni tra farmaci
Hydroxychloroquine + Vandetanib
Gravità: Controindicata
Hydroxychloroquine and Vandetanib: contraindicated interaction.
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Sintesi
Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its labeling advises avoiding other QT-prolonging drugs. Hydroxychloroquine adds to this risk.
Cosa significa questa interazione in parole semplici
Hydroxychloroquine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Vandetanib belongs to Oncology.
Perché avviene
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
Cosa fare
Do not combine; use an alternative to hydroxychloroquine, or if unavoidable, monitor ECG and electrolytes intensively.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Controindicata
- Cisapride + Hydroxychloroquine Controindicata
- Dronedarone + Hydroxychloroquine Controindicata
- Hydroxychloroquine + Pimozide Controindicata
- Hydroxychloroquine + Thioridazine Controindicata
- Adagrasib + Hydroxychloroquine Maggiore
Altre interazioni di Vandetanib
- Amiodarone + Vandetanib Controindicata
- Amisulpride + Vandetanib Controindicata
- Amitriptyline + Vandetanib Controindicata
- Anagrelide + Vandetanib Controindicata
- Asenapine + Vandetanib Controindicata
- Chloroquine + Vandetanib Controindicata
Domande frequenti
Can I take Hydroxychloroquine with Vandetanib?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its labeling advises avoiding other QT-prolonging drugs. Hydroxychloroquine adds to this risk.
How serious is the interaction between Hydroxychloroquine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative to hydroxychloroquine, or if unavoidable, monitor ECG and electrolytes intensively.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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