Interazioni tra farmaci
Isavuconazole + Sirolimus
Gravità: Maggiore
Isavuconazole and Sirolimus: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Isavuconazole, a moderate CYP3A4 inhibitor, can increase sirolimus concentrations, leading to toxicity such as hyperlipidemia, cytopenias, impaired wound healing, and infections. The size of the effect is smaller than with voriconazole or posaconazole but still clinically important and variable between patients. The isavuconazonium label recommends monitoring sirolimus concentrations.
Cosa significa questa interazione in parole semplici
Isavuconazole and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isavuconazole belongs to Anti Fungals; Sirolimus belongs to Miscellaneous.
Perché avviene
Isavuconazole inhibits CYP3A4 (and P-glycoprotein), reducing the metabolism and efflux of sirolimus.
Cosa fare
Measure sirolimus trough before starting isavuconazole, then frequently during co-therapy, and reduce the sirolimus dose as guided by levels. Reassess levels after isavuconazole is stopped, since sirolimus may need to be increased again.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Isavuconazole
- Carbamazepine + Isavuconazole Controindicata
- Efavirenz + Isavuconazole Controindicata
- Etravirine + Isavuconazole Controindicata
- Isavuconazole + Ketoconazole Controindicata
- Isavuconazole + Phenobarbitone Controindicata
- Isavuconazole + Phenytoin Controindicata
Altre interazioni di Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Controindicata
- Bcg vaccine live + Sirolimus Controindicata
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Controindicata
- Ketoconazole + Sirolimus Controindicata
- Levoketoconazole + Sirolimus Controindicata
- Measles mumps and rubella vaccine live + Sirolimus Controindicata
Domande frequenti
Can I take Isavuconazole with Sirolimus?
MediHelp rates the interaction as major. Isavuconazole and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isavuconazole, a moderate CYP3A4 inhibitor, can increase sirolimus concentrations, leading to toxicity such as hyperlipidemia, cytopenias, impaired wound healing, and infections. The size of the effect is smaller than with voriconazole or posaconazole but still clinically important and variable between patients. The isavuconazonium label recommends monitoring sirolimus concentrations.
How serious is the interaction between Isavuconazole and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure sirolimus trough before starting isavuconazole, then frequently during co-therapy, and reduce the sirolimus dose as guided by levels. Reassess levels after isavuconazole is stopped, since sirolimus may need to be increased again.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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