Interazioni tra farmaci
Isavuconazonium + Secobarbital
Gravità: Controindicata
Isavuconazonium and Secobarbital: contraindicated interaction.
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Sintesi
Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
Cosa significa questa interazione in parole semplici
Isavuconazonium and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Secobarbital belongs to Central Nervous System.
Perché avviene
Barbiturate-mediated CYP3A4 induction increases isavuconazole clearance.
Cosa fare
Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Controindicata
- Doravirine + Secobarbital Controindicata
- Elbasvir / grazoprevir + Secobarbital Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Controindicata
- Lonafarnib + Secobarbital Controindicata
- Lorlatinib + Secobarbital Controindicata
Altre interazioni di Isavuconazonium
- Amobarbital + Isavuconazonium Controindicata
- Apalutamide + Isavuconazonium Controindicata
- Carbamazepine + Isavuconazonium Controindicata
- Cisapride + Isavuconazonium Controindicata
- Efavirenz + Isavuconazonium Controindicata
- Enzalutamide + Isavuconazonium Controindicata
Domande frequenti
Can I take Isavuconazonium with Secobarbital?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
How serious is the interaction between Isavuconazonium and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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