Interazioni tra farmaci
Isocarboxazid + Levodopa
Gravità: Controindicata
Isocarboxazid and Levodopa: contraindicated interaction.
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Sintesi
Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
Cosa significa questa interazione in parole semplici
Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
Perché avviene
Nonselective MAO inhibition prevents breakdown of dopamine and norepinephrine formed from levodopa, producing excessive adrenergic stimulation.
Cosa fare
Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Altre interazioni di Levodopa
- Levodopa + Phenelzine Controindicata
- Levodopa + Phenelzine (nonselective MAOI) Controindicata
- Levodopa + Procarbazine Controindicata
- Levodopa + Tranylcypromine Controindicata
- Amisulpride + Levodopa Maggiore
- Chlorpromazine + Levodopa Maggiore
Domande frequenti
Can I take Isocarboxazid with Levodopa?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.
How serious is the interaction between Isocarboxazid and Levodopa?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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