Interazioni tra farmaci
Ketoconazole + Rifaximin
Gravità: Moderata
Ketoconazole and Rifaximin: moderate interaction.
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Sintesi
Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
Cosa significa questa interazione in parole semplici
Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Rifaximin belongs to Anti Bacterial.
Perché avviene
P-glycoprotein inhibition by ketoconazole decreases rifaximin efflux.
Cosa fare
Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Rifaximin
- Cholera vaccine + Rifaximin Maggiore
- Microbiota + Rifaximin Maggiore
- Amiodarone + Rifaximin Moderata
- Bcg intravesical live + Rifaximin Moderata
- Cyclosporine + Rifaximin Moderata
- Cyclosporin + Rifaximin Moderata
Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Conivaptan + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
Domande frequenti
Can I take Ketoconazole with Rifaximin?
MediHelp rates the interaction as moderate. Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
How serious is the interaction between Ketoconazole and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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