Interazioni tra farmaci
Magnesium hydroxide + Raltegravir
Gravità: Maggiore
Magnesium hydroxide and Raltegravir: major interaction.
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Sintesi
Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
Cosa significa questa interazione in parole semplici
Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium hydroxide belongs to Gastrointestinal Tract; Raltegravir belongs to Anti Virals.
Perché avviene
Chelation of raltegravir by magnesium cations in the gastrointestinal tract reduces absorption.
Cosa fare
Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Magnesium hydroxide
- Ciprofloxacin + Magnesium hydroxide Maggiore
- Dolutegravir + Magnesium hydroxide Maggiore
- Gemifloxacin + Magnesium hydroxide Maggiore
- Levofloxacin + Magnesium hydroxide Maggiore
- Magnesium hydroxide + Moxifloxacin Maggiore
- Magnesium hydroxide + Ofloxacin Maggiore
Altre interazioni di Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Controindicata
- Aluminum hydroxide / magnesium carbonate + Raltegravir Maggiore
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Maggiore
- Aluminum hydroxide + Raltegravir Maggiore
- Atidarsagene autotemcel + Raltegravir Maggiore
- Betibeglogene autotemcel + Raltegravir Maggiore
Domande frequenti
Can I take Magnesium hydroxide with Raltegravir?
MediHelp rates the interaction as major. Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
How serious is the interaction between Magnesium hydroxide and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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