Interazioni tra farmaci
Mercaptopurine + Ublituximab
Gravità: Maggiore
Mercaptopurine and Ublituximab: major interaction.
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Sintesi
Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.
Cosa significa questa interazione in parole semplici
Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mercaptopurine belongs to Oncology; Ublituximab belongs to Miscellaneous.
Perché avviene
Additive immunosuppression from anti-CD20 B-cell depletion and purine antimetabolite lymphocyte and marrow suppression.
Cosa fare
Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Controindicata
- Azathioprine + Mercaptopurine Controindicata
- Bcg vaccine live + Mercaptopurine Controindicata
- Febuxostat + Mercaptopurine Controindicata
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Controindicata
- Mercaptopurine + Smallpox vaccine live Controindicata
Altre interazioni di Ublituximab
- Azathioprine + Ublituximab Maggiore
- Baricitinib + Ublituximab Maggiore
- Cyclosporin + Ublituximab Maggiore
- Fingolimod + Ublituximab Maggiore
- Leflunomide + Ublituximab Maggiore
- Natalizumab + Ublituximab Maggiore
Domande frequenti
Can I take Mercaptopurine with Ublituximab?
MediHelp rates the interaction as major. Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.
How serious is the interaction between Mercaptopurine and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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