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Azathioprine + Mercaptopurine

Gravità: Controindicata

Azathioprine and Mercaptopurine: contraindicated interaction.

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Sintesi

Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.

Cosa significa questa interazione in parole semplici

Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Azathioprine belongs to Gastrointestinal Tract; Mercaptopurine belongs to Oncology.

Livello di evidenza: High

Perché avviene

Therapeutic duplication: azathioprine is a prodrug of mercaptopurine, so both generate the same cytotoxic thioguanine nucleotides.

Cosa fare

Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Azathioprine with Mercaptopurine?

MediHelp rates the interaction as contraindicated. Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.

How serious is the interaction between Azathioprine and Mercaptopurine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.

What other medicines interact with Mercaptopurine?

MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Mercaptopurine page.

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