Interazioni tra farmaci
Ondansetron + Thioridazine
Gravità: Controindicata
Ondansetron and Thioridazine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ondansetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive QT prolongation through blockade of cardiac potassium channels.
Cosa fare
Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ondansetron
- Apomorphine + Ondansetron Controindicata
- Ondansetron + Vandetanib Controindicata
- Adagrasib + Ondansetron Maggiore
- Amiodarone + Ondansetron Maggiore
- Amisulpride + Ondansetron Maggiore
- Amoxapine + Ondansetron Maggiore
Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Domande frequenti
Can I take Ondansetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Ondansetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Vandetanib, Adagrasib. The full list is on the Ondansetron page.
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