Interazioni tra farmaci
Oxytocin + Phenylephrine
Gravità: Maggiore
Oxytocin and Phenylephrine: major interaction.
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Sintesi
Oxytocin may cause hypotension, while vasopressors given with it can cause severe hypertension. Labeling for oxytocin warns that vasoconstrictors given with it can lead to hypertensive episodes.
Cosa significa questa interazione in parole semplici
Oxytocin and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxytocin belongs to Endocrine; Phenylephrine belongs to Respiratory.
Perché avviene
Additive pharmacodynamic effects; oxytocin-related vascular changes combined with alpha-1 vasoconstriction.
Cosa fare
Monitor blood pressure closely, for example during obstetric anesthesia, and titrate phenylephrine in small doses.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Phenylephrine
- Isocarboxazid + Phenylephrine Controindicata
- Phenelzine + Phenylephrine Controindicata
- Phenylephrine + Tranylcypromine Controindicata
- Bromocriptine + Phenylephrine Maggiore
- Cocaine + Phenylephrine Maggiore
- Dihydroergotamine intranasal + Phenylephrine Maggiore
Altre interazioni di Oxytocin
- Carboprost tromethamine + Oxytocin Maggiore
- Dinoprostone + Oxytocin Maggiore
- Ephedrine + Oxytocin Maggiore
- Fexinidazole + Oxytocin Maggiore
- Givinostat + Oxytocin Maggiore
- Misoprostol + Oxytocin Maggiore
Domande frequenti
Can I take Oxytocin with Phenylephrine?
MediHelp rates the interaction as major. Oxytocin and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxytocin may cause hypotension, while vasopressors given with it can cause severe hypertension. Labeling for oxytocin warns that vasoconstrictors given with it can lead to hypertensive episodes.
How serious is the interaction between Oxytocin and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, for example during obstetric anesthesia, and titrate phenylephrine in small doses.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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