Interazioni tra farmaci
Avanafil + Tipranavir
Gravità: Controindicata
Avanafil and Tipranavir: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
Cosa significa questa interazione in parole semplici
Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Perché avviene
Ritonavir-boosted tipranavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of avanafil, reducing its clearance.
Cosa fare
Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Avanafil e Tipranavir, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Avanafil
- Amyl nitrite + Avanafil Controindicata
- Atazanavir + Avanafil Controindicata
- Avanafil + Clarithromycin Controindicata
- Avanafil + Conivaptan Controindicata
- Avanafil + Darunavir Controindicata
- Avanafil + Fosamprenavir Controindicata
Altre interazioni di Tipranavir
- Alfuzosin + Tipranavir Controindicata
- Amiodarone + Tipranavir Controindicata
- Atorvastatin + Tipranavir Controindicata
- Cisapride + Tipranavir Controindicata
- Colchicine + Tipranavir Controindicata
- Dronedarone + Tipranavir Controindicata
Domande frequenti
Can I take Avanafil with Tipranavir?
MediHelp rates the interaction as contraindicated. Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
How serious is the interaction between Avanafil and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
