Interazioni tra farmaci
Colchicine + Tipranavir
Gravità: Controindicata
Colchicine and Tipranavir: contraindicated interaction.
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Sintesi
Tipranavir, given with ritonavir, inhibits CYP3A4 and P-glycoprotein and can substantially increase colchicine concentrations. This raises the risk of severe or fatal colchicine toxicity, especially in renal or hepatic impairment.
Cosa significa questa interazione in parole semplici
Colchicine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Perché avviene
Ritonavir-boosted tipranavir inhibits CYP3A4 and P-glycoprotein, decreasing colchicine clearance.
Cosa fare
Avoid in patients with renal or hepatic impairment. Otherwise use an alternative if possible, or reduce the colchicine dose per labeling and monitor closely for toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Cyclosporine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Levoketoconazole Controindicata
- Colchicine + Nirmatrelvir Controindicata
Altre interazioni di Tipranavir
- Alfuzosin + Tipranavir Controindicata
- Amiodarone + Tipranavir Controindicata
- Atorvastatin + Tipranavir Controindicata
- Avanafil + Tipranavir Controindicata
- Cisapride + Tipranavir Controindicata
- Dronedarone + Tipranavir Controindicata
Domande frequenti
Can I take Colchicine with Tipranavir?
MediHelp rates the interaction as contraindicated. Colchicine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, given with ritonavir, inhibits CYP3A4 and P-glycoprotein and can substantially increase colchicine concentrations. This raises the risk of severe or fatal colchicine toxicity, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal or hepatic impairment. Otherwise use an alternative if possible, or reduce the colchicine dose per labeling and monitor closely for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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