Interazioni tra farmaci
Sapropterin + Tadalafil
Gravità: Moderata
Sapropterin and Tadalafil: moderate interaction.
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Sintesi
Sapropterin is a cofactor for nitric oxide synthase and may increase nitric oxide production. Combined with a PDE5 inhibitor this could cause additive vasodilation and low blood pressure.
Cosa significa questa interazione in parole semplici
Sapropterin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sapropterin belongs to Miscellaneous; Tadalafil belongs to Genitourinary.
Perché avviene
Sapropterin may enhance nitric oxide synthesis while tadalafil prolongs cGMP signalling, a theoretical additive vasodilatory effect.
Cosa fare
Monitor blood pressure when the drugs are started together or doses changed. Counsel patients to report dizziness or fainting.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Tadalafil
- Amyl nitrite + Tadalafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Nitroglycerin po + Tadalafil Controindicata
- Nitroglycerin rectal + Tadalafil Controindicata
- Nitroglycerin sublingual + Tadalafil Controindicata
Altre interazioni di Sapropterin
- Avanafil + Sapropterin Moderata
- Carbidopa-entacapone-levodopa + Sapropterin Moderata
- Carbidopa-levodopa + Sapropterin Moderata
- Levodopa + Sapropterin Moderata
- Methotrexate + Sapropterin Moderata
- Phenobarbitone + Sapropterin Moderata
Domande frequenti
Can I take Sapropterin with Tadalafil?
MediHelp rates the interaction as moderate. Sapropterin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for nitric oxide synthase and may increase nitric oxide production. Combined with a PDE5 inhibitor this could cause additive vasodilation and low blood pressure.
How serious is the interaction between Sapropterin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the drugs are started together or doses changed. Counsel patients to report dizziness or fainting.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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