Interazioni tra farmaci
Valoctocogene roxaparvovec + Valproic acid
Gravità: Maggiore
Valoctocogene roxaparvovec and Valproic acid: major interaction.
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Sintesi
Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
Cosa significa questa interazione in parole semplici
Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valoctocogene roxaparvovec belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
Perché avviene
Additive hepatotoxicity from two hepatotoxic agents.
Cosa fare
Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Valproic acid
- Ertapenem + Valproic acid Controindicata
- Imipenem / cilastatin / relebactam + Valproic acid Controindicata
- Imipenem / cilastatin + Valproic acid Controindicata
- Meropenem / vaborbactam + Valproic acid Controindicata
- Meropenem + Valproic acid Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Maggiore
Altre interazioni di Valoctocogene roxaparvovec
Domande frequenti
Can I take Valoctocogene roxaparvovec with Valproic acid?
MediHelp rates the interaction as major. Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
How serious is the interaction between Valoctocogene roxaparvovec and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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