医薬品リファレンス
Brigatinib
Brigatinib is a medicine in the class oncology. It is used for non-small cell lung cancer.
- 薬効分類: Oncology
- 効能・効果: non-small cell lung cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- ATCコード
- L01XE43
- 一般的な剤形
- 錠剤
- 一般的な規格
- 180 mg
- 既知の相互作用
- 48 (重大: 23 · 中等度: 21 · 軽度: 4)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Brigatinib is a tyrosine kinase inhibitor with in vitro activity against multiple kinases including ALK, ROS1, IGF-1R and FLT-3, as well as EGFR deletion and point mutations. It inhibits ALK autophosphorylation and downstream signaling (STAT3, AKT, ERK1/2, S6).
成人の通常用量（添付文書の要約）
ALK-positive metastatic NSCLC: 90 mg orally once daily for the first 7 days, then increase to 180 mg orally once daily; continue until disease progression or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unsafe ALK inhibitor: can cause fetal harm; no human data. Check pregnancy status first. Women: effective contraception during treatment and for 4 months after; men with female partners: 3 months.
- 授乳
- Unsafe No human milk data. Do not breastfeed during treatment and for 1 week after the last dose.
報告されている副作用
- Diarrhea
- Fatigue
- Nausea
- Rash
- Cough
- Myalgia
注意が必要な方
- ILD/pneumonitis: monitor for new or worsening respiratory symptoms, especially in the first week; withhold and evaluate; discontinue permanently for Grade 3 or 4.
- Hypertension: monitor blood pressure after 2 weeks and at least monthly; withhold, reduce or discontinue for severe cases.
- Bradycardia: monitor heart rate and blood pressure; review concomitant bradycardic drugs.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (48)
- Amobarbital + Brigatinib Major
- Apalutamide + Brigatinib Major
- Brigatinib + Carbamazepine Major
- Brigatinib + Clarithromycin Major
- Brigatinib + Desogestrel-ethinyl estradiol Major
- Brigatinib + Efavirenz Major
- Brigatinib + Enzalutamide Major
- Brigatinib + Ethinyl estradiol-drospirenone Major
- Brigatinib + Ethinyl estradiol-levonorgestrel Major
- Brigatinib + Ethinyl estradiol-norgestimate Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Brigatinibの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Brigatinib used for?
Brigatinib is a medicine in the class oncology. It is used for Non-small cell lung cancer.
What side effects have been reported with Brigatinib?
Diarrhea, Fatigue, Nausea, Rash, Cough, Myalgia.
Can Brigatinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. ALK inhibitor: can cause fetal harm; no human data. Check pregnancy status first. Women: effective contraception during treatment and for 4 months after; men with female partners: 3 months. Breastfeeding: Unsafe. No human milk data. Do not breastfeed during treatment and for 1 week after the last dose.
What does Brigatinib interact with?
MediHelp lists 48 known interactions for Brigatinib. Major: 23 · Moderate: 21 · Minor: 4. The most serious include Amobarbital, Apalutamide, Carbamazepine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
