相互作用
Brigatinib + Clarithromycin
重症度: 重大
Brigatinib and Clarithromycin: major interaction.
最終更新日
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概要
Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.
この相互作用をわかりやすく説明すると
Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of brigatinib.
対処法
Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrigatinibとClarithromycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Brigatinibのその他の相互作用
よくある質問
Can I take Brigatinib with Clarithromycin?
MediHelp rates the interaction as major. Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.
How serious is the interaction between Brigatinib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
